Myo-Inositol & D-Chiro Inositol | Hormone Balance for Women | Ideal 40:1 Ratio | Myo Inositol 2000mg, D Chiro 50mg | Vitamin B8 to Regulate Menstrual Cycle & Support Ovarian Health | SM Nutrition

Product Information

Aromatase is an enzyme involved in the transformation of androgens to estrogens; hence the inhibition of its activity ends up causing an increase in the levels of testosterone and other androgens. Taking extra folic acid is indicated primarily for those trying to conceive or those who have deficiency.

Aside from the 40 : 1 ratio, the other ratios are very imaginative and seem to have been randomly chosen. Combining treatment with myo-inositol andD-chiro-inositol (40:1) is effective in restoring ovary function and metabolic balance in PCOS patients. Ovasitol is the first and only 40:1 inositol supplement that’s independently tested and certified by NSF International®, so you know exactly what you’re getting. The reduction of the ratio under this value was shown to exert negative consequences on blastocyst quality, assessed as grades 2 and 1 blastocysts.

By supporting your body’s hormone rhythms, this fertile supplement can help with metabolism, energy, bloating, skin health, and more. Simply put, if you don’t have sex during your fertile window – those 3-5 days just before you ovulate – you can’t get pregnant. The primary outcome was ovulation, and the secondary outcomes included the improvement of FSH, LH, sex hormone-binding globulin (SHBG), 17-beta-estradiol (E2), free testosterone, and basal and postprandial insulin levels, as well as HOMA index, BMI, and menses. Indeed, although muscle and liver are insulin resistant in women with PCOS, the ovaries retain normal insulin sensitivity, highlighting the tissue-specificity of insulin resistance in PCOS.

Inositols can cause mild side effects in some people, like nausea, diarrhoea, headaches and dizziness.Please consult your doctor before starting any exercise or nutritional supplement program or before using these or any product during pregnancy or if you have a serious medical condition. A published study successfully related the concentrations of MI and DCI in follicular fluid (FF) to the quality of blastocysts. We, Time Health Ltd, reserve the right to make changes to our policies, and these terms and conditions at any time. Supplement with this 40:1 ratio has been shown to be more effective than either form of inositol alone. Recently, treatment of PCOS patients with different natural molecules, coming from nutritional supplements and herbal medicines, has attained satisfactory results with the absence of any side effects.

A potential explanation for this phenomenon is the tissue-specific nature of insulin resistance in women with PCOS.Those authors highlighted that various studies demonstrated the role of DCI at low dosage to increase insulin sensitivity and ovulation regularity and to reduce the levels of lipid biomarkers and serum androgen. The oocytes were taken from strictly healthy young women (egg donors) who were subjected to ovarian stimulation, whereas the sperm used for fertilization was given by the male partner of each couple undergoing IVF (all men were normospermic).

Read more about the condition New: A brand-new, unused, unopened and undamaged item in original retail packaging (where packaging is applicable). Sacchi and coworkers [ 44] stimulated primary cultures of human granulosa cells (hGCs) by insulin and tested the aromatase CYP19A1 gene expression by Real-Time PCR to find out whether DCI, after 24 h incubation, inhibited the insulin effect. The authors postulated that the resulting deficiency of MI could be responsible for the poor oocyte quality and the impairment of the FSH signaling. MI-DI combination improves insulin sensitivity, ameliorates the ovulation process, and reduces oxidative stress. Unlike the other organs, the ovary is never insulin resistant and, in PCOS woman, it becomes rich in d-chiro inositol.They used four concentrations of DCI, namely, 1, 5, 10, and 20 nM: the first one was totally ineffective, 5 nM exerted a barely visible inhibitory activity, whereas 10 and 20 nM achieved a significant inhibitory effect that became greater with increasing DCI concentrations (slightly more than 50% reduction with 20 nM DCI). Treated patients, compared with controls, obtained an increased frequency of spontaneous menstrual cycles, and this finding suggested that MI may be useful in the treatment of infertility in PCOS [ 18]. In our discussion of vitamins, we focus our attention on vitamin D since it can offer valuable adjunctive therapy for pregnancy if correctly administered [ 56] during the luteal phase (and not in the follicular phase) of the menstrual cycle.